French Open runner-up Simona Halep is seeded second after reaching a career-best ranking this month. She has never advanced past the fourth round at the U.S. Open.
Wimbledon champ Petra Kvitova is seeded No. 3 with third-ranked Li Na out because of a knee injury. Agnieszka Radwanska moves up to No. 4.
Five-time major champ Maria Sharapova is seeded fifth, meaning there’s a chance she could face Williams in the quarterfinals. The runner-up the last two years, Victoria Azarenka, is seeded 16th after an injury-plagued season.
Venus Williams is seeded 19th.
The draw is Thursday, and the tournament starts Monday.