NFL sends 49ers back to Mexico City in Week 11 after Melbourne opener on 9-game international slate | The Courier The San Francisco 49ers will bookend the NFL 's largest ever international slate, playing the 2026 season opener in Melbourne against the NFC West rival Los Angeles Rams and facing the Minnesota Vikings in Week 11 in Mexico City.

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NFL sends 49ers back to Mexico City in Week 11 after Melbourne opener on 9-game international slate